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Wilkening, S

During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)

Biologically plausible domain of applicability All the key events described should be conserved among animal species, suggesting that the AOP may also have relevance for amphibians, reptiles, birds and and invertebrates with sexual reproduction

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Excessive drowsiness or fatigue Strong drowsiness suggests individual sensitivity to melatonin modulation